NEW DELHI: HIV drugs lopinavir and ritonavir — which were initially tried in India against Covid-19 for a brief period — have not shown any significant benefit in treatment of hospitalized COVID-19 patients or in reducing mortality among them, researchers in the RECOVERY trial at the University of Oxford have reported. The trial steering committee decided there is no beneficial effect of lopinavir and ritonavir combination in patients hospitalised with Covid-19 and closed randomisation to that treatment arm. “These data convincingly rule out any meaningful mortality benefit of lopinavir-ritonavir in the hospitalised Covid-19 patients we studied,” the researchers said in a statement. A total of 1,596 patients were randomised to Lopinavir-Ritonavir and compared to 3,376 patients randomised to usual care
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